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Publications by ISAPP Board
Michael Cabana, MD, MPH
  • Cabana MD, Shane AL, Chao C, Oliva-Hemker M. Probiotics in primary care pediatrics. Clin Peds. 2006;45:405-410.
  • Cabana MD, McKean M, Wong AR, Chao C, Caughey AB. Examining the hygiene hypothesis: the Trial of Infant Probiotic Supplementation. Paediatr Perinat Epid. 2007; 21:s23-28.
  • Lenoir-Wijnkoop I, Sanders ME, Cabana MD, Van Loo J, Sherman PM, Rayes N, Timmerman HM, Corthier G, Vaneechoutte M, Caglar E, Volvers DAW. Probiotic and probiotic influence beyond the intestinal tract. Nutrition Reviews. 2007;65:469-89
Nathalie Delzenne, Ph.D.
  • Delzenne NM, Cani PD. A place for dietary fibre in the management of the metabolic syndrome.Curr Opin Clin Nutr Metab Care. 2005 Nov;8(6):636-40 (2005).
  • Cani PD, Joly E, Horsmans Y, Delzenne NM. Oligofructose promotes satiety in healthy human: a pilot study. Eur J Clin Nutr. May 60(5):567-72 (2006).
  • Cani P, Hoste S, Guiot Y, Delzenne N Dietary non digestible carbohydrates promote L cell differentiation in the proximal colon of rat. Br J Nutr 98, 32-37 (2007).
  • Delzenne N., Cani P, Neyrinck A. Gut peptides and energy metabolism: experimental data with Inulin and Oligofructose J. Nutr., 137 (11S ) 2547S-2551S (2007).
  • Cani PD, Neyrinck AM, Fava F, Knauf C, Burcelin RG, Tuohy KM, Gibson GR, Delzenne N. Selective increases of bifidobacteria in gut microflora improves high-fat diet - induced diabetes through a mechanisms associated with endotoxemia. Diabetologia 50, 2374-2380 (2007).
  • Cani PD, Delzenne NM. Gut microflora as a target for energy and metabolic homeostasis Current Opinion in Clinical Nutrition and Metabolic Care, 10, 729-734 (2007).
  • Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck A, Delzenne NM, Burcelin R Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57(6),1470-81 (2008)
Glenn Gibson, Ph.D.
  • Depeint, F., Tzortzis, G., Vulevic, J., I'anson, K. and Gibson GR. 2008. Prebiotic evaluation of a novel galactooligosaccharide mixture produced by the enzymatic activity of Bifidobacterium bifidum NCIMB 41171, in healthy humans: a randomized, double-blind, crossover, placebo-controlled intervention study. American Journal of Clinical Nutrition 87, 785-791.
  • Vulevic, J. and Gibson, G.R. 2008. In vitro effects of phosphatidylcholine and transgalactooligosaccharides on the production of 1,2-sn-diacylglycerol by Bifidobacterium longum biovar infantis. Journal of Applied Microbiology 105, 1678-1685.
  • Vulevic, J., Drakoularakou, A., Yaqoob, P., Tzortzis, G. and Gibson, G.R. 2008. Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers. American Journal of Clinical Nutrition 88, 1438-1446.
  • Goulas, T., Goulas, A., Tzortzis, G. and Gibson, G.R. 2009. A novel alpha-galactosidase from Bifidobacterium bifidum with transgalactosylating properties: gene molecular cloning and heterologous expression. Applied Microbiology and Biotechnology 82, 471-477.
  • Goulas, T., Goulas, A., Tzortzis, G. and Gibson, G.R. 2009. Comparative analysis of four beta-galactosidases from Bifidobacterium bifidum NCIMB41171: purification and biochemical characterisation. Applied Microbiology and Biotechnology 82, 1079-1088.
  • Silk, D.B., Davis, A., Vulevic, J., Tzortzis, G. and Gibson, G.R. 2009. Clinical trial: the effects of a trans-galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome. Alimentary Pharmacology and Therapy 29, 508-518.
  • Goulas, T., Goulas, A., Tzortzis, G. and Gibson, G.R. 2009. Expression of four beta-galactosidases from Bifidobacterium bifidum NCIMB41171 and their contribution on the hydrolysis and synthesis of galactooligosaccharides. Applied Microbiology and Biotechnology 84, 899-907.
  • Drakoularakou, A., Tzortzis, G., Rastall, R.A. and Gibson, G.R. 2009. A double-blind, placebo-controlled, randomized human study assessing the capacity of a novel galacto-oligosaccharide mixture in reducing travellers' diarrhoea. European Journal of Clinical Nutrition – in press.
Francisco Guarner, MD, Ph.D.
  • Guarner F, Malagelada JR. Gut flora in health and disease. Lancet 2003; 361:512-519.
  • Cummings JH, Antoine JM, Azpiroz F, Bourdet-Sicard R, Brandtzaeg P, Calder PC, Gibson GR, Guarner F, Isolauri E, Pannemans D, Shortt C, Tuijtelaars S, Watzl B. PASSCLAIM--gut health and immunity. Eur J Nutr 2004; 43 Suppl 2: 118-173.
  • Guarner F. Probiotics. In "Therapy of Digestive Disorders", Wolfe MM, Davis GL, Farraye FA, Giannella R, Malagelada JR, Steer ML eds. 2nd Edition, Saunders Elsevier, Philadelphia 2006, 33-41.
  • Carol M, Borruel N, Antolin M, Llopis M, Casellas F, Guarner F, Malagelada JR. Modulation of apoptosis in intestinal lymphocytes by a probiotic bacteria in Crohn’s disease. J Leukocyte Biol 2006; 79: 917-922.
  • Guarner F. Hygiene, microbial diversity and immune regulation. Curr Opin Gastroenterol. 2007; 23: 667-672.
  • Casellas F, Borruel N, Torrejon A, Varela E, Antolin M, Guarner F, Malagelada JR. Oral oligofructose-enriched inulin supplementation in acute ulcerative colitis is well tolerated and associated with lowered faecal calprotectin. Aliment Pharmacol Ther 2007; 25:1061-1067.
  • Martinez C, Antolin M, Santos J, Torrejon A, Casellas F, Borruel N, Guarner F, Malagelada JR. Unstable composition of the fecal microbiota in ulcerative colitis during clinical remission. Am J Gastroenterol 2008; 103: 643-8.
  • Giralt J, Regadera JP, Verges R, Romero J, de la Fuente I, Biete A, Villoria J, Cobo JM, Guarner F. Effects of probiotic Lactobacillus casei DN-114 001 in prevention of radiation-induced diarrhea: results from multicenter, randomized, placebo-controlled nutritional trial. Int J Radiat Oncol Biol Phys 2008; 71: 1213-9.
Todd Klaenhammer, Ph.D.
  • Klaenhammer, T.R., R. Barrangou, B.L. Buck, M.A. Azcarate-Peril, E.Altermann. 2005. Genomic features of lactic acid bacteria effecting bioprocessing and health. FEMS Microbiology Reviews. 29:393-409.
  • Azcarate Peril, M.A., O. McAuliffe, E. Altermann, S.Lick, W. M. Russell, and T.R. Klaenhammer. 2005. Microarray Analysis of a Two Component Regulatory System Involved in Acid Resistance and Proteolytic Activity in Lactobacillus acidophilus. Appl. Envir. Microbiol. 71: 5794 5804.
  • Mohamadzadeh, M., S. Olson, W.V. Kalina, G. Ruthel, G.L. Demmin, K.L. Warfield, S.Bavari, and T. R. Klaenhammer. 2005. Lactobacilli activate human dendritic cells that skew T cells toward T-helper 1 polarization. Proc. Nat. Acad. Sci. USA. 102:2280-2285.
  • Altermann, E. , W. M. Russell, M.A.Azcarate-Peril, R. Barrangou, B.L.Buck, O. McAuliffe, N. Souther, A. Dobsen, T. Doung, M. Callanan, S. Lick, A. Hamrick, R. Cano, and T.R. Klaenhammer. 2005. Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM. Proc. Nat. Acad. Sci. USA 102: 3906-3912.
  • Barrangou, R., M.A. Azcarate-Peril, T.Duong, S.B. Conners, R.M. Kelly, and T.R. Klaenhammer. 2006. Global analysis of carbohydrate utilization by Lactobacillus acidophilus using cDNA microarrays. Proc. Nat. Acad. Sci. USA 103: 3816-3821.
  • Azcarate-Peril MA, Altermann E, Goh YJ, Tallon R, Sanozky-Dawes RB, Pfeiler EA, O'Flaherty S, Buck BL, Dobson A, Duong T, Miller MJ, Barrangou R, Klaenhammer TR. 2008. Analysis of the genome sequence of Lactobacillus gasseri ATCC 33323 reveals the molecular basis of an autochthonous intestinal organism. Appl Environ Microbiol. 74:4610-4625.
  • Konstantinov, S.R., H. Smidt, W.M. de Vos, S.C.M. Bruijns, S.K. Singh, F. Valence, D. Molle, S. Lortal, E. Altermann, T.R. Klaenhammer, Y. van Kooyk. 2008. S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functions. PNAS published online before print December 1, 2008, doi:10.1073/pnas.0810305105.
Gregor Reid, Ph.D., MBA, Dr, HS
  • Laughton, J., Devillard, E., D. Heinrichs, G. Reid, and J. McCormick. 2006. Inhibition of expression of a staphylococcal superantigen-like protein by a secreted signaling factor from Lactobacillus reuteri. Microbiology 152: 1155-1167.
  • Kim, S. O., Sheik, H. I., S-D. Ha, A. Martins, and G. Reid. 2006. G-CSF mediated inhibition of JNK is a key mechanism for Lactobacillus rhamnosus-induced anti-inflammatory effects in macrophages. Cell. Microbiol. 8(12):1958-1971.
  • Liu JJ, Reid G, JiangY, Turner MS, Tsai C-C. 2007. Expression of HIV-inactivating proteins by recombinant human vaginal probiotic Lactobacillus reuteri RC-14. Cell. Microbiol. 9(1):120-30.
  • Baroja, M. L., Kirjavainen, P. V., Hekmat, S. and Reid, G. 2007. Anti-inflammatory effects of probiotic-yogurt in inflammatory bowel disease patients. Clin Experimental Immunol. 149:470-9.
  • Cadieux, P., A. Wind, P. Sommer, L. Schaefer, K. Crowley, R. A. Britton, and G. Reid. 2008. Evaluation of reuterin production in urogenital probiotic Lactobacillus reuteri RC-14. Appl. Environ. Microbiol. 74(15):4645-9.
  • Martins, A. J., P. Colquoun, G. Reid and S. O. Kim. 2008. Reduced expression of basal and probiotic-inducible G-CSF in intestinal mononuclear cells is associated with inflammatory bowel disease. Inflamm Bowel Dis. 15(4):515-25.
  • Yeganegi, M, C. S. Watson, A. Martins, S. O. Kim, G. Reid, J. R. G. Challis and A. D. Bocking. 2009. Effect of Lactobacillus rhamnosus GR-1 supernatant and fetal sex on lipopolysaccharide-induced cytokine and prostaglandin-regulating enzymes in human placental trophoblast cells: Implications for treatment of bacterial vaginosis and prevention of preterm labour. Amer. J. Obstetr. Gynecol. 200(5):532.e1-8.
  • Delzenne, N., and G. Reid. 2009. No causal link between probiotics and obesity. Nature Reviews Microbiology, 7(12):901
Mary Ellen Sanders, Ph.D.
  • Sanders ME. 2008. Use of Probiotics and Yogurts in Maintenance of Health. J Clin Gastroenterol. 42 Suppl 2:S71-S74.
  • Douglas L and Sanders ME. 2008. Probiotics and prebiotics in dietetic practice. J Amer Dietetics Assoc. 108:510-521.
  • Sanders, M.E. Probiotics: Definition, Source, Selection and Uses. 2008. Clin Infect Dis. 46(S2):S58-S61.
  • Lenoir-Wijnkoop I, Sanders, M.E., Van Loo, J., Rayes, N., Timmerman, H., Sherman, P. Cabana, M., Corthier, G., Charbonneau, D., Vaneechoutte, M., Caglar, E., Wolvers, D., Manneck, I. 2007. Probiotic and prebiotic influence beyond the intestinal tract. Nutr Rev. 65:469-489.
  • Sanders M.E., Gibson G.R., Gill H. and Guarner F. 2007. Probiotics in food: their potential to impact human health. Council for Agricultural Science and Technology (CAST), Issue Paper 36, CAST, Ames, Iowa. Download free from http://www.cast-science.org/displayProductDetails.asp?idProduct=144.
  • Quigley, E.M.M. and Sanders, M.E. 2009. Probiotic Foods for Gastrointestinal Health. Gastroenterology & Endoscopy News Special Edition. October;7:27-33.
  • Sanders, M.E., Marco, M. Food formats for effective delivery of probiotics. Ann Rev Food Sci Technol, In Press.
  • Sanders, M.E., Merenstein, D.J. Use of probiotic yogurts in health and disease. In, Probiotics: Clinical Guide, M. Floch, A. Kim, Eds., Slack Inc. In Press.
  • Sanders, M.E. 2009. How do we know when something called “probiotic” is really a probiotic? A guideline for consumers and healthcare professionals. Functional Food Rev 1:3-12. Download free from http://journals.bcdecker.com/pubs/FFR/volume%2001,%202009/issue%2001,%20Spring/FFR_2009_00002/FFR_2009_00002.pdf.
Karen Scott, Ph.D.
  • Scott, K.P., Martin, J.C., Campbell, G., Mayer, C-D. and Flint, H.J. 2006. Whole genome transcription profiling reveals genes up-regulated by growth on fucose in the human gut bacterium Roseburia inulinivorans. Journal of Bacteriology 188, 4340-4349.
  • Patterson, A.J., Colangeli, R., Spigaglia, P. and Scott, K.P. 2007. Distribution of specific tetracycline and erythromycin resistance genes in environmental samples assessed by macroarray detection. Environmental Microbiology 9, 703-715.
  • Patterson, A.J., Rincon, M.T., Flint, H.J. and Scott, K.P. 2007. Mosaic tetracycline resistance genes are widespread in human and animal fecal samples. Antimicrobial Agents and Chemotherapy 51, 1115-1118.
  • Duncan, S.H., Scott, K.P., Ramsay, A.G., Harmsen, H.J.M., Welling, G.W., Stewart, C.S. and Flint, H.J. 2003. Effects of alternative dietary substrates on competition between human colonic bacteria in an anaerobic fermentor system. Applied and Environmental Microbiology. 69, 1136-1142.
  • Chassard, C., Scott, K.P., Marquet, P., Martin, J.C., Del’Homme, C., Dapoigny, M., Flint, H.J. and Bernalier-Donadille, A. 2008. Assessment of metabolic diversity within the intestinal microbiota from healthy humans using combined molecular and cultural approaches. FEMS Microbiology Ecology 66, 496-504.
  • Scott, K.P., Duncan, S.H. and Flint, H.J. 2008. Dietary fibre and the gut microbiota. British Nutrition Foundation Bulletin 33, 201-211.
  • Kazimierczak, K.A., Rincon, M.T., Patterson, A.J., Martin, J.C., Young, P., Flint, H.J. and Scott, K.P. 2008. A new tetracycline efflux gene, tet(40), is located in tandem with tet(O/32/O), in a human gut Firmicute bacterium and in metagenomic library clones. Antimicrobial Agents and Chemotherapy 52, 4001-4009.
  • Scott, K.P. Martin, J.C., Mrazek, J., and Flint, H.J. 2008. Transfer of conjugative elements from rumen and human Firmicutes bacteria to Roseburia inulinivorans. Applied and Environmental Microbiology 74, 3915-3917.
  • Ramsay, A.G., Scott, K.P., Martin, J.C., Rincon, M.T. and Flint, H.J. 2006. Cell-associated -amylases of butyrate-producing Firmicute bacteria from the human colon. Microbiology 152, 3281-3290.
James Versalovic, MD, Ph.D.
  • Whitehead K, Versalovic J, Roos S, Britton RA. (2008) Genomic and genetic characterization of the bile stress response of probiotic Lactobacillus reuteri ATCC 55730. Applied Environ Microbiol: 74:1812-9. [PMC2268311]
  • Spinler JK, Taweechotipatr M, Rognerud CL, Ou CN, Tumwasorn, Versalovic J. (2008) Human-derived probiotic Lactobacillus reuteri demonstrate antimicrobial activities targeting diverse enteric bacterial pathogens. Anaerobe: 14:166-171. [NIHMS57384]
  • Iyer C, Kosters A, Sethi G, Kunnamakara A, Aggarwal BB, Versalovic J. (2008) Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-?B and MAPK signaling. Cell Microbiol: 10:1442-52.
  • Lin YP, Thibodeaux CH, Peña JA, Ferry GD, Versalovic J. (2008) Probiotic Lactobacillus reuteri suppress proinflammatory cytokines via c-Jun. Inflamm Bowel Dis: 14:1068-83.
  • Versalovic J, Iyer C, Lin YP, Huang Y, Dobrogosz W. (2008) Commensal-derived probiotics as anti-inflammatory agents. Microb Ecol Health Dis: 20:86-93.
  • McGuire AL, Colgrove J, Whitney SN, Diaz CM, Bustillos D, Versalovic J. (2008) Ethical, legal, and social considerations in conducting the Human Microbiome Project. Genome Res [Epub ahead of print].
  • Hsieh MH, Versalovic J. (2008) The human microbiome and probiotics: implications for pediatrics. Curr Probl Pediatr Adolesc Health Care: 38:309-27.
  • Therapeutic Microbiology: Probiotics and Related Strategies. (Eds. Versalovic J and Wilson M) (2008). American Society for Microbiology Press, Washington DC.
Dr. George C. Fahey, Jr.
  • K. A. Barry, B. M. Vester, and G. C. Fahey, Jr. 2009. Prebiotics in companion and livestock animal nutrition. In: Prebiotics and Probiotics Science and Technology. D. Charalampopoulos and R. Rastall, editors. pp. 353-463. Springer, New York, NY.
  • B. M. Vester and G. C. Fahey, Jr. 2010. Prebiotics and probiotics in companion animal nutrition. In: Handbook of Prebiotics and Probiotics Ingredients: Health Benefits and Food Applications. S. S. Cho and E. T. Finocchiaro, editors. pp. 355-380. CRC Press, Boca Raton, FL.
  • B. M. Vester Boler, D. C. Hernot, T. W. Boileau, L. L. Bauer, I. S. Middelbos, M. R. Murphy, K. S. Swanson, and G. C. Fahey, Jr. 2009. Carbohydrates blended with polydextrose lower gas production and short-chain fatty acid production in an in vitro system. Nutr. Res. 29:631-639.
  • D. C. Hernot, T. W. Boileau, L. L. Bauer, I. S. Middelbos, M. R. Murphy, K. S. Swanson, and G. C. Fahey, Jr. 2009. In vitro fermentation profiles, gas production rates, and microbiota modulation as affected by certain fructans, galactooligosaccharides, and polydextrose. J. Agric. Food Chem. 57:1354-1361.
  • K. A. Barry, D. C. Hernot, I. S. Middelbos, C. Francis, B. Dunsford, K. S. Swanson, and G. C. Fahey, Jr. 2009. Low-level fructan supplementation of dogs enhances nutrient digestion and modifies stool metabolite concentrations, but does not alter fecal microbiota populations. J. Anim. Sci. 87:3244-3252.
  • B. K. Knapp, C. M. Parsons, K. S. Swanson, and G. C. Fahey, Jr. 2008. Physiological responses to novel carbohydrates as assessed using canine and avian models. J. Agric. Food Chem. 56:7999-8006.
  • D. C. Hernot, T. W. Boileau, L. L. Bauer, K. S. Swanson, and G. C. Fahey, Jr. 2008. In vitro digestion characteristics of unprocessed and processed whole grains and their components. J. Agric. Food Chem. 56:10721-10726.
  • N. D. Fastinger, L. K. Karr-Lilienthal, J. K. Spears, K. S. Swanson, K. E. Zinn, G. M. Nava, K. Ohkuma, S. Kanhori, D. T. Gordon, and G. C. Fahey, Jr. 2008. A novel resistant maltodextrin alters gastrointestinal tolerance factors, fecal characteristics, and fecal microbiota in healthy adult humans. J. Amer. Coll. Nutr. 27:356-366.
Colin Hill, Ph.D.
  • Casey P.G., G.E. Gardiner, G. Casey, B. Bradshaw, P.G. Lawlor, P.B. Lynch, F.C. Leonard, C. Stanton, R.P. Ross, C. Hill and G.F. Fitzgerald. 2007. A five-strain probiotic combination reduces pathogen shedding and alleviates disease signs in pigs challenged with Salmonella typhimurium Appl. Environ. Microbiol. 73:1858-1863.

  • Corr, S.C., Y. Li, C.U. Riedel, P.W. O’Toole, C. Hill, C.G.M. Gahan. 2007. From the cover: Bacteriocin production as a mechanism for the anti-infective activity of Lactobacillus salivarius UCC118. Proc. Natl. Acad. Sci. 104:7617-7621.

  • Corr, S., C.G.M. Gahan and C. Hill. 2007. Impact of selected Lactobacillus and Bifidobacterium species on Listeria monocytogenes infection and the mucosal immune response. FEMS Immunol. Med. Microbiol. 50:380-388.

  • Sleator, R.D. and C. Hill. 2007. Probiotics as therapeutics for the developing world. J. Infect. Developing Countries. 1:7-12.

  • Sheehan, V.M., R.D Sleator, C. Hill and G.F. Fitzgerald. 2007. Improving gastric transit, gastrointestinal persistence and therapeutic efficacy of the probiotic strain Bifidobacterium breve UCC2003. Microbiology 153:3563-3571.

  • Klosterman, K. F. Crispie, J. Flynn, R.P. Ross C. Hill and W. Meaney. 2008. Intramammary infusion of a live culture of Lactococcus lactis for treatment of bovine mastitis: comparison to antibiotic treatment in field trials. J. Dairy Res. 75:365-373.

  • Crispie, F., M. Alonso-Gomez, C. O’Loughlin, K. Klostermann, J. Flynn, S. Arkins, W. Meaney, R.P. Ross and C. Hill. 2008. Intramammary infusion of a live culture for treatment of bovine mastitis: effect of live lactococci on the mammary immune response. J. Dairy Res. 75:374-384.

  • Corr, S., C.G.M. Gahan and C. Hill. 2008. Understanding the mechanisms by which probiotics inhibit gastrointestinal pathogens. Adv. Food Nutrition Res. 56:1-15.

  • Sleator, R.D. and C. Hill. 2008. Battle of the bugs (letter). Science 321: 1294-1295.

  • Beecher, C., M. Daly, D.P. Berry, K. Klostermann, J. Flynn, W. Meaney, C. Hill, T.V. McCarthy, R.P. Ross and L. Giblin. 2009. Administration of a live culture of Lactococcus lactis DPC 3147 into the bovine mammary gland stimulates the local host immune response, particularly IL-1β and IL-8 gene expression. J. Dairy Res. 76:340-348.

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To engender and disseminate information on high quality, multidisciplinary, scientific investigation in the fields of probiotics and prebiotics, and to advance the development of scientifically substantiated, health-promoting probiotic and prebiotic products worldwide.


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